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White, Steven

One or more keywords matched the following properties of White, Steven

Property	Value
first name	Steven
full name	Steven White
label	White, Steven
overview	I have 30 years of experience in the study of asthma, airways inflammation and airways remodeling, with a focus to understand why inflammation persists and why repair is aberrant in airways. My focus in recent years has been on the initial response to airway injury in cell biology-focused studies. Along with this, I have focused on understanding clinical parameters important to the care of patients with asthma. I have successfully administered several major NIH-funded grants, all of which have required significant collaborations with investigators from diverse fields and which have generated peer-reviewed publications in key biomedical journals. More recently, I have focused on understanding clinical parameters important to the care of patients with asthma. I was contact PI in a U19 funded Asthma and Allergic Diseases Cooperative Research Center funded by NIAID. Our asthma program was just awarded a UG1 for precision medicine in severe and exacerbation prone asthma (the “PrecISE” protocol). I also co-direct our hospital-wide COPD clinical program that focuses on readmissions and the transitions from hospital to outpatient and community medicine. Our multi-disciplinary group has already “bent the curve” downward substantially in readmissions, and I direct the clinical support team that provides direct patient care. More recent work from our program examines the role of the epithelium in host-defense responses to the airway microbiome; we have the largest single-center study to state and currently are examining the relationship of the fungal microbiome (the ‘mycobiome’) to the bacterial microbiome in asthma. All of this is dedicated to the idea that understanding the basic and translational science of the lungs will lead to better therapies for asthma.

One or more keywords matched the following items that are connected to White, Steven

Item Type	Name
Concept	Amyotrophic Lateral Sclerosis
Concept	Anastomosis, Surgical
Concept	Electric Stimulation
Concept	Carcinoma, Non-Small-Cell Lung
Concept	Cell Separation
Concept	Evaluation Studies as Topic
Concept	Drug Synergism
Concept	Muscle, Smooth
Concept	Genes, Dominant
Concept	Genes
Concept	Hypertonic Solutions
Concept	Muscle, Smooth, Vascular
Concept	Heat-Shock Proteins
Concept	Intensive Care Units
Concept	Saphenous Vein
Concept	Vasomotor System
Concept	Cohort Studies
Concept	Saline Solution, Hypertonic
Concept	Solubility
Concept	Serotonin
Concept	Swine
Concept	Sympathomimetics
Concept	Sheep
Concept	Skin
Concept	Sympathetic Nervous System
Concept	SRS-A
Concept	Stress, Mechanical
Concept	Superoxides
Concept	Sputum
Concept	United States
Concept	Wounds, Stab
Concept	Protein Subunits
Concept	Rats, Sprague-Dawley
Concept	Sequence Analysis, DNA
Concept	Muscle, Skeletal
Concept	L-Selectin
Concept	Intercellular Signaling Peptides and Proteins
Concept	Oligonucleotide Array Sequence Analysis
Concept	Stress Fibers
Concept	STAT3 Transcription Factor
Concept	Respiratory System
Concept	HSP27 Heat-Shock Proteins
Concept	Severity of Illness Index
Concept	Substance P
Concept	Steroids
Concept	Adaptor Proteins, Signal Transducing
Concept	Sucrose
Concept	Survival Analysis
Concept	Smad7 Protein
Concept	In Situ Nick-End Labeling
Concept	MAP Kinase Signaling System
Concept	Genome-Wide Association Study
Concept	Insulin Receptor Substrate Proteins
Concept	Receptors, Prostaglandin E, EP1 Subtype
Concept	RNA, Small Interfering
Concept	Molecular Sequence Annotation
Concept	Intracellular Signaling Peptides and Proteins
Concept	STAT6 Transcription Factor
Concept	Cell Survival
Concept	Ganglia, Spinal
Concept	Growth Substances
Concept	Rhinitis, Allergic, Seasonal
Concept	Longitudinal Studies
Concept	Prospective Studies
Concept	Retrospective Studies
Concept	Self Administration
Concept	Simian virus 40
Concept	Signal Transduction
Concept	Polymorphism, Single Nucleotide
Concept	NF-kappa B p50 Subunit
Concept	Sirtuin 1
Academic Article	Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.
Academic Article	Effect of mode of activation of human eosinophils on tracheal smooth muscle contraction in guinea pigs.
Academic Article	Physiologic significance of epithelial removal on guinea pig tracheal smooth muscle response to acetylcholine and serotonin.
Academic Article	Mechanisms of smooth muscle contraction elicited by cationic proteins in guinea pig trachealis.
Academic Article	Secondary diagnoses as predictive factors for survival or mortality in Medicare patients with acute pneumonia.
Academic Article	EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis.
Academic Article	Characterization of cell surface lectin-binding patterns of human airway epithelium.
Academic Article	Topographic distribution of prostaglandin secretion caused by bradykinin in canine tracheal epithelial cells.
Academic Article	Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo.
Academic Article	Airway epithelial cell wound repair mediated by alpha-dystroglycan.
Academic Article	Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons.
Academic Article	Role of very late adhesion integrins in mediating repair of human airway epithelial cell monolayers after mechanical injury.
Academic Article	Oxygen metabolism and catecholamine secretion during chloralose anesthesia in lambs.
Academic Article	Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps.
Academic Article	Anastomotic intimal hyperplasia: mechanical injury or flow induced.
Academic Article	Fas cross-linking induces apoptosis in human airway smooth muscle cells.
Academic Article	Trefoil peptides in airway epithelium: an important addition to the plethora of peptides.
Academic Article	Direct effects on airway smooth muscle contractile response caused by endothelin-1 in guinea pig trachealis.
Academic Article	Epithelial modulation of airway smooth muscle response to endothelin-1.
Academic Article	Rho kinase inhibition initiates apoptosis in human airway epithelial cells.
Academic Article	Corticosteroid-induced apoptosis of airway epithelium: a potential mechanism for chronic airway epithelial damage in asthma.
Academic Article	Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation.
Academic Article	Efficacy of daily routine chest radiographs in intubated, mechanically ventilated patients.
Academic Article	Effect of beta-adrenergic blockade and sympathetic stimulation on canine bronchial mast cell response to immune degranulation in vivo.
Academic Article	Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction.
Academic Article	Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells.
Academic Article	Epithelium-dependent contraction of airway smooth muscle caused by eosinophil MBP.
Academic Article	Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine.
Academic Article	Human leucocyte antigen-G: expression and function in airway allergic disease.
Academic Article	Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro.
Academic Article	Effects of vasomotor- and mediator-induced hypotension on bronchomotor tone in swine.
Academic Article	Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.
Academic Article	Sympathetic secretory response to hypercapnic acidosis in swine.
Academic Article	Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils.
Academic Article	Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin.
Academic Article	Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis.
Academic Article	Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture.
Academic Article	Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells.
Academic Article	Epithelial augmentation of trachealis contraction caused by major basic protein of eosinophils.
Academic Article	Antagonism of relaxation to isoproterenol caused by agonist interactions.
Academic Article	Stimulation of migration and wound repair of guinea-pig airway epithelial cells in response to epidermal growth factor.
Academic Article	Prostaglandin secretion by guinea pig tracheal epithelial cells caused by eosinophil major basic protein.
Academic Article	Direct effects and augmentation of airway smooth muscle contraction caused by phospholipase A2.
Academic Article	Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article	Stress-activated protein kinases mediate cell migration in human airway epithelial cells.
Academic Article	Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4.
Academic Article	Safety and feasibility of bronchial thermoplasty in asthma patients with very severe fixed airflow obstruction: a case series.
Academic Article	Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
Academic Article	Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article	Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
Academic Article	A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.
Academic Article	Genome-wide interrogation of longitudinal FEV1 in children with asthma.
Academic Article	Association of soluble HLA-G with acute rejection episodes and early development of bronchiolitis obliterans in lung transplantation.
Academic Article	Glycosylation and annexin II cell surface translocation mediate airway epithelial wound repair.
Academic Article	Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.
Academic Article	Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-beta1 in human airway epithelial cells.
Academic Article	Venous thromboembolism after diaphragm pacing in amyotrophic lateral sclerosis.
Academic Article	Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation.
Academic Article	Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells.
Academic Article	Bronchial thermoplasty failure in severe persistent asthma: a case report.
Academic Article	Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge.
Academic Article	Effects of corticosteroid-induced apoptosis on airway epithelial wound closure in vitro.
Academic Article	Peripheral blood IRF1 expression as a marker for glucocorticoid sensitivity.
Academic Article	Airway Inflammation after Bronchial Thermoplasty for Severe Asthma.
Academic Article	A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis.
Academic Article	Lynx: a knowledge base and an analytical workbench for integrative medicine.
Academic Article	Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis.
Academic Article	Virtual Teach-To-Goal™ Adaptive Learning of Inhaler Technique for Inpatients with Asthma or COPD.
Academic Article	Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.
Academic Article	The metabolic footprint of the airway bacterial community in cystic fibrosis.
Grant	Chicago Metropolitan Asthma Consortium for severe / exacerbation-prone asthma
Concept	Visual Analog Scale
Grant	CORTICOSTEROID INDUCED APOPTOSIS IN AIRWAY EPITHELIUM
Grant	Role of epithelial HLA-G in lung transplantation
Grant	EPITHELIAL MODULATION OF RESPIRATORY SMOOTH MUCSCLE
Grant	Azithromycin and the airway microbiome in asthma
Grant	MECHANISMS OF AIRWAY EPITHELIUM APOPTOSIS
Grant	Airway inflammation and HLA-G in asthma
Grant	IL-6 high phenotype in childhood asthma
Grant	Regulation of airway epithelial repair
Grant	SYMPATHETIC REGULATION OF BRONCHOMOTOR TONE
Grant	EPITHELIAL FUNCTION--REGULATION IN AIRWAY RESPONSIVENESS
Grant	GROWTH AND REPAIR OF AIRWAY EPITHELIUM IN ASTHMA

Search Criteria

National Institute of Allergy and Infectious Diseases
U
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